> For the complete documentation index, see [llms.txt](https://docs.rplpeptides.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.rplpeptides.com/docs/retatrutide/technical-data-sheets/retatrutide-technical-data-sheet.md).

# retatrutide-technical-data-sheet

RPL Peptide

Official Technical Documentation

Technical Data Sheet

***

## Retatrutide (GLP-1R/GIPR/GCGR Triple Agonist)

### Product Overview

Retatrutide is a synthetic 39-amino-acid triple receptor agonist peptide engineered to simultaneously interact with three distinct receptor systems: glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR). This multi-agonist architecture differentiates Retatrutide from earlier incretin-focused compounds by enabling researchers to examine how multiple hormonal pathways influence metabolic regulation simultaneously.

### Product Specifications

| Parameter                   | Specification                                        |
| --------------------------- | ---------------------------------------------------- |
| **Product Name**            | Retatrutide                                          |
| **CAS Number**              | 2381089-83-2                                         |
| **Synonyms**                | Triple GLP-1R/GIPR/GCGR Receptor Agonist Peptide     |
| **Amino Acid Count**        | 39 Amino Acids                                       |
| **Molecular Weight**        | \~4,900 Da                                           |
| **Peptide Type**            | Synthetic Modified Peptide                           |
| **Classification**          | Triple Incretin/Glucagon Receptor Agonist            |
| **Appearance**              | White to Off-White Lyophilized Powder                |
| **Purity (HPLC)**           | ≥99.0%                                               |
| **Peptide Content**         | 70–90%                                               |
| **Water Content (KF)**      | <5%                                                  |
| **Endotoxin**               | <5 EU/mg                                             |
| **Solubility**              | Soluble in water, PBS, saline                        |
| **pH (1% Solution)**        | 4.0–6.5                                              |
| **Storage (Lyophilized)**   | -20°C (2+ years)                                     |
| **Storage (4°C)**           | 12 months                                            |
| **Reconstituted Stability** | 2–8°C for 30 days                                    |
| **Package Sizes**           | 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg vial |
| **Certification**           | COA, HPLC, LC-MS                                     |

### Receptor Targets

| Receptor   | Type                                                  | Research Significance                  |
| ---------- | ----------------------------------------------------- | -------------------------------------- |
| **GLP-1R** | Glucagon-like peptide-1 receptor                      | Incretin signaling, insulin secretion  |
| **GIPR**   | Glucose-dependent insulinotropic polypeptide receptor | Nutrient-responsive signaling          |
| **GCGR**   | Glucagon receptor                                     | Energy metabolism, glucose homeostasis |

### Quality Assurance

Each batch is tested using validated analytical methods:

* HPLC purity analysis at 214 nm
* LC-MS molecular weight confirmation (±0.5 Da)
* UPLC chromatographic profiling
* Water content by Karl Fischer (KF)
* Endotoxin testing (LAL method)
* Batch-specific Certificate of Analysis (COA)
* Third-party analytical validation available upon request

### Reconstitution Protocol

1. Equilibrate vial to room temperature (15–25°C).
2. Briefly centrifuge to collect powder at vial bottom.
3. Add bacteriostatic water (0.9% benzyl alcohol) against inner wall.
4. Swirl gently — DO NOT vortex or shake vigorously.
5. Clear solution = complete reconstitution.
6. Recommended concentration: 1–5 mg/mL.

### Regulatory & Disclaimer

This product is for laboratory research use only. NOT for human or veterinary consumption, medical treatment, diagnosis, or therapeutic application. All research must comply with applicable regulations.

***

© 2026 RPL Peptide

Official Technical Documentation

rplpeptides.com


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