> For the complete documentation index, see [llms.txt](https://docs.rplpeptides.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.rplpeptides.com/docs/motsc/01-overview/motsc-overview.md).

# motsc-overview

### Chapter 01: Product Overview

### 1.1 Introduction

MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA Type-C) is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded by the mitochondrial 12S rRNA gene. It belongs to the family of mitochondrial-encoded peptides that mediate inter-organellar communication and regulate metabolic homeostasis. MOTS-C has garnered significant research interest for its roles in metabolic regulation, exercise physiology, insulin sensitivity, and age-related metabolic decline.

Unlike nuclear-encoded peptides, MOTS-C is transcribed and translated within the mitochondria, a unique biosynthetic origin that positions it as a mitochondrial signaling molecule capable of translocating to the nucleus under cellular stress conditions (e.g., glucose restriction, AMPK activation) to regulate gene expression.

### 1.2 Product Identification

| Parameter                  | Specification                          |
| -------------------------- | -------------------------------------- |
| **Product Name**           | MOTS-C (Mitochondrial-Derived Peptide) |
| **CAS Number**             | 1627580-64-6                           |
| **Molecular Formula**      | C₁₀₁H₁₅₂N₂₈O₂₂S₂                       |
| **Molecular Weight**       | 2,174.62 Da                            |
| **Peptide Length**         | 16 amino acids                         |
| **Sequence**               | MRWQEMGYIFYPRKLR                       |
| **Type**                   | Linear synthetic peptide               |
| **Isoelectric Point (pI)** | \~11.3 (basic)                         |
| **Net Charge at pH 7.4**   | +3 (positive)                          |

### 1.3 Product Specifications

| Attribute         | Standard                                                       |
| ----------------- | -------------------------------------------------------------- |
| **Purity**        | ≥98% (HPLC, 214 nm)                                            |
| **Appearance**    | White to off-white lyophilized powder                          |
| **Packaging**     | 10 mg, 20 mg, 40 mg per vial                                   |
| **Box Contents**  | 10 vials per box                                               |
| **Pricing Range** | $68–$196 per box (varies by quantity and packaging)            |
| **Storage**       | 2–8 °C (short-term, ≤6 months); –20 °C (long-term, ≥12 months) |
| **Shelf Life**    | 24 months when stored at –20 °C                                |
| **Solubility**    | Soluble in water, PBS, and saline                              |

### 1.4 Classification

* **Molecular Class:** Mitochondrial-derived peptide (MDP)
* **Gene Origin:** MT-RNR2 (12S rRNA gene)
* **Therapeutic Research Areas:** Metabolic syndrome, type 2 diabetes, obesity, sarcopenia, NAD⁺ metabolism, exercise mimetics, aging research
* **Regulatory Status:** For laboratory research use only. Not for human or veterinary therapeutic use.

### 1.5 Manufacturer Information

**RPL Peptide** Qingdao RPL Biotechnology Co., Ltd. Official Website: <https://rplpeptides.com>

RPL Peptide is a professional manufacturer and supplier of high-purity synthetic peptides for research purposes. All products are manufactured under controlled laboratory conditions and subjected to rigorous quality control (QC) testing including HPLC, LC-MS, and UPLC analysis. Each batch is accompanied by a Certificate of Analysis (COA).

### 1.6 Related Documents

| Document            | Description                                             |
| ------------------- | ------------------------------------------------------- |
| RPL-TM-MOT-001      | Complete Technical Documentation Manual (this document) |
| RPL-TM-MOT-001-COA  | Certificate of Analysis                                 |
| RPL-TM-MOT-001-SDS  | Safety Data Sheet                                       |
| RPL-TM-MOT-001-MS   | Mass Spectrometry Analysis Report                       |
| RPL-TM-MOT-001-HPLC | HPLC Chromatogram Report                                |

***

*End of Chapter 01 — Product Overview*

*Document ID: RPL-TM-MOT-001 | Chapter 01 | Version 1.0 | July 2026* *Publisher: RPL Peptide (Qingdao RPL Biotechnology Co., Ltd.)*


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